Rheumatoid Factor - Quantitative

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What is RF Quant.?

Rheumatoid factor (RF) test determines the presence of rheumatoid antibodies in the body. These are the autoantibodies produced by body's own immune system that attack the healthy tissues. Presence of high level of RF antibodies might indicate the presence of serious autoimmune disorders such as rheumatoid arthritis, lupus erythematosus, chronic infections like tuberculosis and leukemia.

Symptoms like joints pain, fatigue, weight loss, fever, weakness, lumps formation may be suggestive of RF antibodies and testing is usually advised in such cases. Some other tests are also recommended in conjunction with RF test to reach a definitive diagnosis.

Why is RF Quant. done?

    • To diagnose rheumatic diseases such as Rheumatoid arthritis
    • To diagnose autoimmune diseases such as Sjogren’s syndrome or Lupus Erythematosus
    • To diagnose chronic infections

What does RF Quant. Measure?

Rheumatoid factor (RF) attacks healthy body tissues as it mistakes them for foreign body tissues. It is not found in healthy persons. The presence of RF means that the body has an autoimmune disease such as Rheumatoid arthritis. Symptoms of Rheumatoid arthritis include stiffness of joints especially in morning, pain in joints, underlying skin nodules, loss of bone and swelling of joints.   

Interpreting RF Quant. results


High levels of Rheumatoid factor test indicates the high level of rheumatoid factor in the blood which is associated with Rheumatoid arthritis.

There are other conditions where RF test is positive that include:

  • Sjogren’s syndrome
  • Systemic Lupus erythematosus
  • Inflammatory lung diseases
  • Chronic infections
  • Cancer
  • Mixed connective tissue diseases